Long-term toxicity of modified recombinant human tumor necrosis factor in Macaca mulatta.

Authors :: Gu CH
Yuan BJ
Lu GC
Dai ZR
Liu JP
Zhang SY
Zhang P
Jiang CL
Source :: Zhongguo yao li xue bao = Acta pharmacologica Sinica [Zhongguo Yao Li Xue Bao] 1998 Jan; Vol. 19 (1), pp. 85-8.
Publication Year :: 1998
Abstract: Aim: To study the long-term toxicity of modified recombinant human tumor necrosis factor (rhTNF-NC) in Macaca mulatta compared with recombinant human tumor necrosis factor (rhTNF).<br />Methods: rhTNF-NC 93, 9.3 GU/m2, and rhTNF 62 GU/m2 were injected i.v. daily to 16 Macaca mulatta for 1 month and 10 d, respectively. Hematologic, chemical, urinalysis values, ECG, specific antibody, bone marrow, and pathologic profile of organs were measured.<br />Results: No more adverse effects of rhTNF-NC were found in spite of anorexia in 4 monkeys and palpebral edema in 2 monkeys of 93 GU/m2 group. Besides, in rhTNF group, the injury of liver and kidneys, the decrease of erythron, the phlebitis, and thrombosis at injection site occurred. Both drugs caused the production of specific antibody.<br />Conclusion: No serious adverse effects of rhTNF-NC were found in Macaca mulatta. The toxicity of rhTNF-NC was much lower than that of rhTNF.

Subjects :: Animals
Bone Marrow Examination
Female
Kidney pathology
Liver pathology
Macaca mulatta
Male
Recombinant Proteins toxicity
Tumor Necrosis Factor-alpha toxicity

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