Involvement of interleukin-2 in analgesia produced by Coriolus versicolor polysaccharide peptides.

Authors :: Gong S
Zhang HQ
Yin WP
Yin QZ
Zhang Y
Gu ZL
Qian ZM
Tang PL
Source :: Zhongguo yao li xue bao = Acta pharmacologica Sinica [Zhongguo Yao Li Xue Bao] 1998 Jan; Vol. 19 (1), pp. 67-70.
Publication Year :: 1998
Abstract: Aim: To study the role of interleukin-2 (IL-2) and mediobasal hypothalamus (MBH) in analgesia produced by Coriolus versicolor polysaccharide peptide (PSP).<br />Methods: The IL-2 antiserum was injected i.c.v. or i.p. and the MBH was destroyed electrolytically.<br />Results: PSP i.g. 1 g.kg-1.d-1 for 6 d increased the pain threshold in tail stimulation-vocalization test in rats. This PSP-produced analgesia was blocked by i.c.v., but not i.p., IL-2 antiserum and disappeared after electrolytic lesion of MBH.<br />Conclusion: The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in the MBH.

Subjects :: Animals
Female
Immune Sera pharmacology
Injections, Intraventricular
Interleukin-2 immunology
Interleukin-2 physiology
Male
Pain Threshold
Peptides isolation & purification
Peptides pharmacology
Polysaccharides isolation & purification
Rats
Rats, Wistar
Analgesics, Non-Narcotic pharmacology
Hypothalamus, Middle physiology
Polyporaceae chemistry
Polysaccharides pharmacology

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