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Involvement of interleukin-2 in analgesia produced by Coriolus versicolor polysaccharide peptides.
- Source :
-
Zhongguo yao li xue bao = Acta pharmacologica Sinica [Zhongguo Yao Li Xue Bao] 1998 Jan; Vol. 19 (1), pp. 67-70. - Publication Year :
- 1998
-
Abstract
- Aim: To study the role of interleukin-2 (IL-2) and mediobasal hypothalamus (MBH) in analgesia produced by Coriolus versicolor polysaccharide peptide (PSP).<br />Methods: The IL-2 antiserum was injected i.c.v. or i.p. and the MBH was destroyed electrolytically.<br />Results: PSP i.g. 1 g.kg-1.d-1 for 6 d increased the pain threshold in tail stimulation-vocalization test in rats. This PSP-produced analgesia was blocked by i.c.v., but not i.p., IL-2 antiserum and disappeared after electrolytic lesion of MBH.<br />Conclusion: The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in the MBH.
- Subjects :
- Animals
Female
Immune Sera pharmacology
Injections, Intraventricular
Interleukin-2 immunology
Interleukin-2 physiology
Male
Pain Threshold
Peptides isolation & purification
Peptides pharmacology
Polysaccharides isolation & purification
Rats
Rats, Wistar
Analgesics, Non-Narcotic pharmacology
Hypothalamus, Middle physiology
Polyporaceae chemistry
Polysaccharides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0253-9756
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhongguo yao li xue bao = Acta pharmacologica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 10375763