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Pharmacological aspects of pyrazoline derivatives from 2-hydroxy-butenolides.
- Source :
-
Arzneimittel-Forschung [Arzneimittelforschung] 1976; Vol. 26 (11), pp. 2050-2. - Publication Year :
- 1976
-
Abstract
- A series of pyrazoline derivatives was synthetised and evaluated for toxicological and pharmacological effects; analgesic, hypnotic, anti-inflammatory, antipyretic and cardiovascular properties were screened. Tested compounds were found to have a low toxicity; one of them showed a good analgesic activity without side effects.
- Subjects :
- Analgesics chemical synthesis
Analgesics toxicity
Animals
Anti-Inflammatory Agents chemical synthesis
Anti-Inflammatory Agents toxicity
Blood Pressure drug effects
Dogs
Female
Hypnotics and Sedatives chemical synthesis
Hypnotics and Sedatives toxicity
Lactones
Lethal Dose 50
Male
Mice
Myocardial Contraction drug effects
Pyrazoles chemical synthesis
Pyrazoles toxicity
Rats
Pyrazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0004-4172
- Volume :
- 26
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Arzneimittel-Forschung
- Publication Type :
- Academic Journal
- Accession number :
- 1037245