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Synthesis and cytotoxicity of aminosterols: activity studies on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6).
- Source :
-
Anticancer research [Anticancer Res] 1999 Mar-Apr; Vol. 19 (2A), pp. 1229-34. - Publication Year :
- 1999
-
Abstract
- Various new aminosterols were synthesized. The antiproliferative activity of these compounds (I-IV) was studied in vitro on a continuous human non small-cell bronchopulmonary carcinoma line (NSCLC-N6) at the cell cycle level. The histograms indicate cell blockage in Phase Gl (compound I-III) associated with a reduction in the number of cells phases S and G2M and appearance of cellular debris derived from cells in Phase G1.
- Subjects :
- Antineoplastic Agents pharmacology
Bronchial Neoplasms pathology
Carcinoma, Non-Small-Cell Lung pathology
G1 Phase drug effects
Humans
Lung Neoplasms pathology
Sterols pharmacology
Structure-Activity Relationship
Tumor Cells, Cultured
Antineoplastic Agents chemical synthesis
Bronchial Neoplasms drug therapy
Carcinoma, Non-Small-Cell Lung drug therapy
Lung Neoplasms drug therapy
Sterols chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 19
- Issue :
- 2A
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 10368680