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Breast cancer risk in ataxia telangiectasia (AT) heterozygotes: haplotype study in French AT families.
- Source :
-
British journal of cancer [Br J Cancer] 1999 Jun; Vol. 80 (7), pp. 1042-5. - Publication Year :
- 1999
-
Abstract
- Epidemiological studies in ataxia telangiectasia (AT) families have suggested that AT heterozygotes could have an increased cancer risk, especially breast cancer (BC) in women. It has also been suggested that an increased sensibility of AT heterozygotes to the effect of ionizing radiation could be responsible for the increased BC risk. BC relative risk (RR) estimation in AT heterozygotes within families ascertained through AT children is presented here. Family data collected included demographic characteristics, occurrence of cancers, past radiation exposures and blood samples. DNA samples were studied using seven ATM linked microsatellites markers allowing AT haplotypes reconstitution. The relative risk of BC was assessed using French estimated incidence rates. A significant increase risk of BC is found among obligate ATM heterozygotes with a point estimate of 3.32 (P = 0.002). BC relative risk calculated according to age is significantly increased among the obligate ATM heterozygotes female relatives with an age < or = 44 years (RR = 4.55, P = 0.005). The BC relative risk is statistically borderline among the obligate ATM heterozygote female relatives with an age > or = 45 years (RR = 2.48, P = 0.08). The estimated BC relative risk among ATM heterozygotes is consistent with previously published data. However, the increased risk is only a little higher than classical reproductive risk factors and similar to the risk associated with a first-degree relative affected by BC.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Breast Neoplasms epidemiology
Breast Neoplasms, Male epidemiology
Child
Child, Preschool
Female
France
Genetic Carrier Screening
Haplotypes
Heterozygote
Humans
Male
Middle Aged
Risk Assessment
Ataxia Telangiectasia complications
Ataxia Telangiectasia genetics
Breast Neoplasms genetics
Breast Neoplasms, Male genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0007-0920
- Volume :
- 80
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 10362113
- Full Text :
- https://doi.org/10.1038/sj.bjc.6690460