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Peripheral neuropathy in systemic lupus erythematosus.
- Source :
-
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society [J Clin Neurophysiol] 1999 Mar; Vol. 16 (2), pp. 164-8. - Publication Year :
- 1999
-
Abstract
- The prevalence of clinically apparent peripheral neuropathy in systemic lupus erythematosus is reported to be between 2% to 18%. The purpose of this prospective case-control study was to determine the prevalence of peripheral neuropathy (PN) using electrodiagnostic criteria. Subgroup analysis was performed to determine whether PN correlated with disease activity, renal involvement, or serum immune markers. Fifty-four systemic lupus erythematosus patients and 30 controls were recruited in the study. The right median, ulnar, peroneal, tibial, and sural sensory and motor nerve conduction studies were obtained. PN in our study was defined as any abnormal values in motor and sensory distal latency, sensory action potential, motor action potential, or conduction velocity affecting 2 or more nerves. Of the 54 patients studied, PN was present in 15 patients (27.8%) of which 4 were symptomatic. There was a significant correlation between PN and anti-SM antibody, and there was a trend showing decreased motor and sensory action potential amplitudes in our systemic lupus erythematosus group compared to the controls. This observation was also seen in an active disease group when compared to those with inactive disease. The amplitude of the action potential was more often affected than the distal latency, and sensory nerves were more susceptible than motor nerves. The sural sensory action potential amplitude appears to be the most sensitive indicator of PN which may be used as an index to monitor disease activity.
- Subjects :
- Adolescent
Adult
Case-Control Studies
Electromyography
Female
Hereditary Sensory and Autonomic Neuropathies blood
Hereditary Sensory and Motor Neuropathy blood
Humans
Lupus Erythematosus, Systemic blood
Male
Middle Aged
Prospective Studies
Evoked Potentials, Motor physiology
Hereditary Sensory and Autonomic Neuropathies diagnosis
Hereditary Sensory and Motor Neuropathy diagnosis
Lupus Erythematosus, Systemic complications
Subjects
Details
- Language :
- English
- ISSN :
- 0736-0258
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
- Publication Type :
- Academic Journal
- Accession number :
- 10359503
- Full Text :
- https://doi.org/10.1097/00004691-199903000-00010