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Prevalence of Helicobacter pylori resistance to metronidazole, clarithromycin, amoxycillin, tetracycline and trovafloxacin in The Netherlands.
- Source :
-
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 1999 Apr; Vol. 43 (4), pp. 511-5. - Publication Year :
- 1999
-
Abstract
- Successful treatment of Helicobacter pylori infection is becoming compromised by emerging resistance. We report the prevalence rates of H. pylori resistance to metronidazole, clarithromycin, amoxycillin, tetracycline and trovafloxacin in The Netherlands. A total of 231 H. pylori clinical isolates were collected throughout the country over a period of 6 months during 1997-1998. The MICs of the above-mentioned antibiotics were determined in a single laboratory. The overall percentage of resistance for clarithromycin and metronidazole was 1.7% and 21.2%, respectively. None of the strains was resistant to amoxycillin or tetracycline. The primary resistance rate of trovafloxacin was as high as 4.7%. Since trovafloxacin has not yet been introduced on to the Dutch market, the resistance is probably induced by the use of other quinolones. Our data indicate that treatment outcome would benefit from susceptibility testing before starting therapy, especially when prescribing metronidazole.
- Subjects :
- Amoxicillin pharmacology
Clarithromycin pharmacology
Drug Resistance, Microbial
Drug Resistance, Multiple
Drug Utilization
Helicobacter Infections drug therapy
Helicobacter pylori growth & development
Helicobacter pylori isolation & purification
Humans
Metronidazole pharmacology
Microbial Sensitivity Tests
Naphthyridines pharmacology
Netherlands
Tetracycline pharmacology
Anti-Bacterial Agents pharmacology
Fluoroquinolones
Helicobacter Infections microbiology
Helicobacter pylori drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0305-7453
- Volume :
- 43
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of antimicrobial chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 10350380
- Full Text :
- https://doi.org/10.1093/jac/43.4.511