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Prognostic factors in primary cutaneous lymphomas other than mycosis fungoides and the Sézary syndrome. The French Study Group on Cutaneous Lymphomas.
- Source :
-
Blood [Blood] 1999 Jun 01; Vol. 93 (11), pp. 3637-42. - Publication Year :
- 1999
-
Abstract
- Prognostic studies of primary cutaneous lymphomas (PCL) other than mycosis fungoides (MF) and the Sézary syndrome (SS; non-MF/SS PCL) have been mainly performed on subgroups or on small numbers of patients by using univariate analyses. Our aim was to identify independent prognostic factors in a large series of patients with non-MF/SS PCL. We evaluated 158 patients who were registered in the French Study Group on Cutaneous Lymphomas database from January 1, 1986 to March 1, 1997. Variables analyzed for prognostic value were: age; sex; type of clinical lesions; maximum diameter, location, and number of skin lesions; cutaneous distribution (ie, local, regional, or generalized); prognostic group according to the European Organization for Research and Treatment of Cancer (EORTC) classification for PCL; B- or T-cell phenotype; serum lactate dehydrogenase (LDH) level; and B symptoms. Univariate and multivariate analyses were performed using a model of relative survival. Forty-nine patients (31%) died. The median relative survival time was 81 months. In univariate analysis, EORTC prognostic group, serum LDH level, B symptoms, and variables related to tumor extension (ie, distribution, maximum diameter, and number of skin lesions) were significantly associated with survival. When these variables were considered together in a multivariate analysis, EORTC prognostic group and distribution of skin lesions remained statistically significant, independent prognostic factors. This study confirms the good predictive value of the EORTC classification for PCL and shows that the distribution of skin lesions at initial evaluation is an important prognostic indicator.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
B-Lymphocytes pathology
Child
Female
Humans
L-Lactate Dehydrogenase blood
Lymphoma blood
Lymphoma physiopathology
Male
Middle Aged
Models, Statistical
Multivariate Analysis
Mycosis Fungoides pathology
Prognosis
Sex Factors
Sezary Syndrome pathology
Skin Neoplasms blood
Skin Neoplasms physiopathology
Survival Analysis
T-Lymphocytes pathology
Lymphoma pathology
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-4971
- Volume :
- 93
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 10339469