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Troglitazone has no effect on red cell mass or other erythropoietic parameters.
- Source :
-
European journal of clinical pharmacology [Eur J Clin Pharmacol] 1999 Apr; Vol. 55 (2), pp. 101-4. - Publication Year :
- 1999
-
Abstract
- Objective: Troglitazone is a new anti-diabetic agent for the treatment of type 2 diabetes. In placebo-controlled trials troglitazone improves glycaemic control, reduces hyperinsulinaemia and has beneficial effects on blood lipids. However, minor, reversible reductions in erythrocyte count, haemoglobin and haematocrit with no associated clinical symptoms have been observed in some troglitazone-treated patients. The primary objective of the present study was to determine if these changes could be explained by a decrease in red cell mass or change in plasma volume.<br />Methods: Twenty-four healthy males were randomized in a double-blind manner to troglitazone (200 or 600 mg per day) or placebo for 6 weeks. Blood samples for the measurement of red cell mass and plasma volume were obtained in the 2 weeks prior to treatment and after 6 weeks of treatment. Reticulocyte and erythrocyte counts, haemoglobin and haematocrit were also measured.<br />Results: At the end of the treatment period there were no statistically significant changes in red cell mass. Similarly there were no changes in reticulocyte count, erythropoietin or soluble transferrin receptors. These data indicate that troglitazone does not affect erythropoiesis. In addition, troglitazone was not associated with increased red blood cell destruction or haemolysis. There was a trend towards increased plasma volume in the troglitazone groups: increases of 2.5 ml x kg(-1) (5.7% increase) in the troglitazone 200 mg group and 3.4 ml x kg(-1) (7.8% increase) in the troglitazone 600 mg group were observed compared with placebo.<br />Conclusion: These data suggest that dilutional effects related to a modest increase in plasma volume may explain the haematological changes seen in other clinical trials with high doses of troglitazone, although this study has shown that the changes in plasma volume are not statistically significant.
- Subjects :
- Adult
Double-Blind Method
Erythrocyte Count drug effects
Erythrocyte Indices drug effects
Erythrocyte Volume drug effects
Hematocrit
Hemoglobins drug effects
Humans
Male
Reticulocytes drug effects
Troglitazone
Chromans pharmacology
Erythrocytes drug effects
Erythropoiesis drug effects
Hypoglycemic Agents pharmacology
Thiazoles pharmacology
Thiazolidinediones
Subjects
Details
- Language :
- English
- ISSN :
- 0031-6970
- Volume :
- 55
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 10335903
- Full Text :
- https://doi.org/10.1007/s002280050602