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[Effects of low-molecular-weight Rehmannia glutinosa polysaccharides on p53 gene expression].
- Source :
-
Zhongguo yao li xue bao = Acta pharmacologica Sinica [Zhongguo Yao Li Xue Bao] 1997 Sep; Vol. 18 (5), pp. 471-4. - Publication Year :
- 1997
-
Abstract
- Aim: To study the effect of low-molecular-weight Rehmannia glutinosa polysaccharides (LRPS) on p53 gene expression.<br />Methods: The level of p53 gene expression was determined by quantitative polymerase chain reaction and autoradiography.<br />Results: The levels of p53 mRNA in Lewis lung cancer tissue were 0.46, 1.52, 1.48, and 1.60 respectively after saline, LRPS 20 and 40 mg.kg-1, and cyclophosphamide 10 mg.kg-1, which were the effective doses inhibiting the growth of tumor tissue cells in vivo. LRPS markedly increased p53 gene expression.<br />Conclusion: LRPS effect on p53 gene expression is one of the mechanisms of antitumor activity.
- Subjects :
- Animals
Female
Gene Expression
Magnoliopsida chemistry
Mice
Mice, Inbred C57BL
Molecular Weight
Polysaccharides chemistry
Polysaccharides isolation & purification
RNA, Messenger genetics
Antineoplastic Agents, Phytogenic pharmacology
Carcinoma, Lewis Lung genetics
Genes, p53
Polysaccharides pharmacology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0253-9756
- Volume :
- 18
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Zhongguo yao li xue bao = Acta pharmacologica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 10322946