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Citrate carrier and lipogenic enzyme activities in lead nitrate-induced proliferative and apoptotic phase in rat liver.

Authors :
Dini L
Giudetti AM
Ruzittu M
Gnoni GV
Zara V
Source :
Biochemistry and molecular biology international [Biochem Mol Biol Int] 1999 Apr; Vol. 47 (4), pp. 607-14.
Publication Year :
1999

Abstract

After in vivo administration of lead nitrate, functional changes of the mitochondrial tricarboxylate carrier and of the cytosolic lipogenic enzymes acetyl-CoA carboxylase and fatty acid synthetase have been detected in rat liver. The rate of citrate transport was greatly reduced in rats during both the proliferative phase (3 days after the lead nitrate administration) and the involutive phase (5 days after the metal injection), which follows hepatic hyperplasia and corresponds to the peak of hepatocyte apoptosis. In both phases, a decrease of the lipogenic enzyme activities has been detected. In treated animals, an alteration of mitochondrial lipid composition has also been found. The modified lipid microenvironment could be responsible for the decreased carrier activity which, in turn, may account for the reduced activities of the lipogenic enzymes.

Details

Language :
English
ISSN :
1039-9712
Volume :
47
Issue :
4
Database :
MEDLINE
Journal :
Biochemistry and molecular biology international
Publication Type :
Academic Journal
Accession number :
10319412
Full Text :
https://doi.org/10.1080/15216549900201653