Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IkappaB alpha/NF-kappaB pathway in limb-girdle muscular dystrophy type 2A.

Subjects

Subjects :

Adolescent
Adult
Biological Transport
Calpain metabolism
Cell Compartmentation
Child
DNA-Binding Proteins genetics
Female
Fetus
Fluorescent Antibody Technique
Humans
Male
Microscopy, Confocal
Muscle, Skeletal metabolism
Muscle, Skeletal pathology
Muscular Dystrophies classification
Muscular Dystrophies enzymology
Muscular Dystrophies pathology
NF-KappaB Inhibitor alpha
NF-kappa B antagonists & inhibitors
Recombinant Proteins metabolism
Apoptosis
Calpain deficiency
Cell Nucleus pathology
DNA-Binding Proteins metabolism
I-kappa B Proteins
Muscular Dystrophies metabolism
NF-kappa B metabolism

Details

Language :

English

ISSN :

1078-8956

Volume :

5

Issue :

5

Database :

MEDLINE

Journal :

Nature medicine

Publication Type :

Academic Journal

Accession number :

10229226

Full Text :

https://doi.org/10.1038/8385