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Evidence that inhibitory neurotransmission differs between the proximal and distal segments of guinea-pig taenia caeci.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1999 Mar 19; Vol. 369 (2), pp. 215-9. - Publication Year :
- 1999
-
Abstract
- The effect of atropine (1 microM) and N(G)-nitro-L-arginine (L-NOARG, 10 microM) on electrical field stimulation induced relaxation in proximal and distal segments of guinea-pig taenia caeci in the presence of guanethidine (4 microM) was studied. The frequency-dependent relaxations were lower in proximal than in distal segments both in the presence and in the absence of atropine. The effect of L-NOARG (an inhibitor of nitric oxide (NO) synthase) on relaxation in the presence of atropine depended on the frequency of electrical stimulation and the segment used; the effect of L-NOARG was greater in proximal segments than in distal segments. In the absence of atropine, the inhibitory effect of L-NOARG was the same in both segments at all frequencies tested. This study demonstrates differences between the opposite extremes of guinea-pig taenia caeci in relaxations induced by electrical stimulation. Our data also show a role of NO that is dependent on the integrity of cholinergic transmission.
- Subjects :
- Animals
Cecum innervation
Dose-Response Relationship, Drug
Drug Interactions
Electric Stimulation
Enzyme Inhibitors pharmacology
Guanethidine pharmacology
Guinea Pigs
In Vitro Techniques
Male
Neurotransmitter Agents physiology
Nitric Oxide Synthase drug effects
Parasympathetic Nervous System physiology
Parasympatholytics pharmacology
Atropine pharmacology
Cecum physiology
Neurotransmitter Agents antagonists & inhibitors
Nitric Oxide pharmacology
Nitroarginine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 369
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 10206181
- Full Text :
- https://doi.org/10.1016/s0014-2999(99)00074-6