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Microvascular protective activity of flavonoid glucuronides fraction from Tulipa gesneriana.
- Source :
-
Phytotherapy research : PTR [Phytother Res] 1999 Mar; Vol. 13 (2), pp. 166-8. - Publication Year :
- 1999
-
Abstract
- A mixture of flavonoid glucuronides, consisting of 7-O-glucuronides of kaempferol and quercetin 3-O-rutinosides, 3-O-gentiobiosides and 3-O-glucosides, was isolated from the perianths of Tulipa gesneriana L. var. 'Paradae'. It showed protective activity against the increased (both chloroform and histamine) skin vascular permeability in rabbits. The protective effect, measured as the reduction in leakage of Evans blue, was 59.8% after peritoneal treatment at a dose of 25 mg/kg, while that of troxerutin was 45.5%.
- Subjects :
- Animals
Flavonoids isolation & purification
Glucuronates isolation & purification
Male
Plant Extracts chemistry
Plant Extracts pharmacology
Rabbits
Vasoconstrictor Agents isolation & purification
Capillary Permeability drug effects
Flavonoids pharmacology
Glucuronates pharmacology
Liliaceae chemistry
Vasoconstrictor Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0951-418X
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Phytotherapy research : PTR
- Publication Type :
- Academic Journal
- Accession number :
- 10190195
- Full Text :
- https://doi.org/10.1002/(SICI)1099-1573(199903)13:2<166::AID-PTR407>3.0.CO;2-L