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Acute hemorrhagic leukoencephalitis in patients with acute myeloid leukemia in hematologic complete remission.
- Source :
-
Haematologica [Haematologica] 1999 Mar; Vol. 84 (3), pp. 270-4. - Publication Year :
- 1999
-
Abstract
- The authors describe the cases of three patients affected by acute myeloid leukemia, in complete remission, who rapidly developed neurologic symptoms leading to death. Neither clinical characteristics, nor radiological or microbiological procedures, allowed an etiological diagnosis of the neurologic syndrome. Post-mortem examination of the brain showed both macroscopic and microscopic findings compatible with acute hemorrhagic leukoencephalitis. The difficulty in distinguishing this entity from other CNS disease-related complications (e.g. leukemia infiltration, drug toxicity, hemorrhages) should not lead to an underestimation of the true incidence of this complication. We believe that with more attention to the possibility of this complication there would probably be both a greater possibility of collecting clinical informations about the real impact of this dramatic disease and a stronger hope of finding the right treatment for it.
- Subjects :
- Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
Atrophy
Autoimmune Diseases etiology
Autoimmune Diseases pathology
Brain pathology
Cerebral Hemorrhage diagnostic imaging
Cerebral Hemorrhage pathology
Coma etiology
Encephalitis diagnostic imaging
Encephalitis pathology
Fatal Outcome
Female
Humans
Infections complications
Leukemia, Monocytic, Acute complications
Magnetic Resonance Imaging
Male
Middle Aged
Remission Induction
Tomography, X-Ray Computed
Cerebral Hemorrhage etiology
Encephalitis etiology
Leukemia, Myeloid complications
Subjects
Details
- Language :
- English
- ISSN :
- 0390-6078
- Volume :
- 84
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- 10189394