Back to Search
Start Over
Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons.
- Source :
-
Life sciences [Life Sci] 1995; Vol. 56 (11-12), pp. 989-92. - Publication Year :
- 1995
-
Abstract
- Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.
- Subjects :
- Alkaloids pharmacology
Animals
Furans
Muscarinic Agonists pharmacology
Muscarinic Antagonists pharmacology
Naphthalenes
Neurons drug effects
Oxotremorine analogs & derivatives
Oxotremorine pharmacology
Patch-Clamp Techniques
Pertussis Toxin
Piperidines
Pirenzepine pharmacology
Rabbits
Rats
Receptors, Muscarinic drug effects
Superior Cervical Ganglion drug effects
Virulence Factors, Bordetella pharmacology
Calcium Channels metabolism
GTP-Binding Proteins metabolism
Neurons metabolism
Receptors, Muscarinic metabolism
Superior Cervical Ganglion metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 56
- Issue :
- 11-12
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 10188803
- Full Text :
- https://doi.org/10.1016/0024-3205(95)00038-8