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Subfertile men with constitutive chromosome abnormalities do not necessarily refrain from intracytoplasmic sperm injection treatment: a follow-up study on 75 Dutch patients.
- Source :
-
Human reproduction (Oxford, England) [Hum Reprod] 1999 Feb; Vol. 14 (2), pp. 318-20. - Publication Year :
- 1999
-
Abstract
- A follow-up study was performed to investigate the impact of the detection of a chromosome abnormality in infertile men who are candidates for intracytoplasmic sperm injection (ICSI) treatment. In this collaborative study between clinical genetics centres and fertility clinics in the Netherlands, 75 ICSI couples of which the male partners had a chromosome abnormality were included. All couples were extensively counselled on the risk of having a chromosomally unbalanced child. Forty-two out of 75 couples chose to proceed with the ICSI treatment. So far, treatment has resulted in a pregnancy in 11 cases. Four of them opted to have invasive prenatal diagnosis. Despite the genetic risks related to a chromosome abnormality in infertile men, a small majority (56%) of the couples did not refrain from the ICSI treatment.
- Subjects :
- Adult
Female
Follow-Up Studies
Humans
Karyotyping
Male
Pregnancy
Pregnancy Rate
Prenatal Diagnosis
Reference Values
Chromosome Aberrations diagnosis
Chromosome Aberrations physiopathology
Chromosome Disorders
Cytoplasm physiology
Infertility, Male genetics
Micromanipulation
Spermatozoa physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0268-1161
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Human reproduction (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 10099971
- Full Text :
- https://doi.org/10.1093/humrep/14.2.318