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[Anxiety-inducing and -inhibiting agents: differential effect of pentagastrins on the white rat behavior].
- Source :
-
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 1998 Oct; Vol. 84 (10), pp. 1100-7. - Publication Year :
- 1998
-
Abstract
- Parenteral administration of des-BOC-Pentagastrin induced the anxiety and fear manifestations, depressing also explorative behaviour in open field experiments in rats. Intranasal administration evoked similar effects, whereas pentagastrin reduced the anxiety level, increasing explorative behaviour. Pentagastrin and des-BOC-Pentagastrin displayed antagonism at the receptor level.
- Subjects :
- Administration, Intranasal
Animals
Avoidance Learning drug effects
Exploratory Behavior drug effects
Fear drug effects
Injections, Intraperitoneal
Male
Motor Activity drug effects
Oligopeptides administration & dosage
Pentagastrin administration & dosage
Pentagastrin pharmacology
Rats
Rats, Wistar
Receptors, Cholecystokinin drug effects
Anxiety physiopathology
Oligopeptides pharmacology
Pentagastrin analogs & derivatives
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-8139
- Volume :
- 84
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
- Publication Type :
- Academic Journal
- Accession number :
- 10097277