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Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 1999 Feb; Vol. 22 (2), pp. 162-4. - Publication Year :
- 1999
-
Abstract
- To prove the relationship between the fluctuation in serum beta-glucuronidase level and hepatotoxicity, an inhibitor of beta-glucuronidase from G. lucidum was isolated and its hepatoprotective activity was investigated. The ether fraction of G. lucidum, which had potent beta-glucuronidase-inhibitory activity, protected against CCl4-induced liver injury. From this ether fraction, ganoderenic acid A, was isolated as the potent inhibitor of beta-glucuronidase. It had a potent hepatoprotective effect against CCl4-induced liver injury. These results suggest that the beta-glucuronidase seems to be closely related to liver injury, which could be prevented by beta-glucuronidase inhibitors.
- Subjects :
- Animals
Carbon Tetrachloride Poisoning prevention & control
Cholestanes chemistry
Cholestanes isolation & purification
Enzyme Inhibitors chemistry
Enzyme Inhibitors isolation & purification
Male
Rats
Rats, Wistar
Spectrum Analysis
Chemical and Drug Induced Liver Injury prevention & control
Cholestanes pharmacology
Enzyme Inhibitors pharmacology
Glucuronidase antagonists & inhibitors
Liver drug effects
Polyporaceae chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0918-6158
- Volume :
- 22
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 10077435
- Full Text :
- https://doi.org/10.1248/bpb.22.162