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Activation in vivo of retroperitoneal fibromatosis-associated herpesvirus, a simian homologue of human herpesvirus-8.
- Source :
-
The Journal of general virology [J Gen Virol] 1999 Feb; Vol. 80 ( Pt 2), pp. 467-475. - Publication Year :
- 1999
-
Abstract
- Retroperitoneal fibromatosis-associated herpesvirus of rhesus macaques (RFHVMm) is a gammaherpesvirus closely related to human herpesvirus-8 (HHV-8), which is thought to be a necessary cofactor for the development of Kaposi's sarcoma (KS) in humans. Here, RFHVMm infection of rhesus macaques exposed to the D-type retrovirus simian retrovirus-2 (SRV-2) is described. Development of SRV-2 viraemia, infection with simian immunodeficiency virus or administration of cyclosporin A could result in persistent RFHVMm viraemia. From this, it is concluded that productive retrovirus infection or otherwise-induced immune suppression has the ability to activate this herpesvirus in vivo. Elevated levels of circulating interleukin-6, a cytokine that plays a central role in KS, were found in RFHVMm-viraemic animals. In viraemic animals, RFHVMm was found in tissues that are common sites for the development of AIDS-associated KS, especially the oral cavity. Together, these data suggest a common biology between RFHVMm infection of macaques and HHV-8 infection and pathogenesis in humans.
- Subjects :
- Acquired Immunodeficiency Syndrome complications
Animals
Base Sequence
DNA Primers genetics
Gammaherpesvirinae pathogenicity
Gammaherpesvirinae physiology
Herpesvirus 8, Human pathogenicity
Herpesvirus 8, Human physiology
Humans
Immune Tolerance
Interleukin-6 blood
Lymphoid Tissue immunology
Macaca mulatta
Retroperitoneal Fibrosis etiology
Retroperitoneal Fibrosis immunology
Retroviruses, Simian growth & development
Retroviruses, Simian pathogenicity
Retroviruses, Simian physiology
Sarcoma, Kaposi etiology
Sarcoma, Kaposi virology
Species Specificity
Tissue Distribution
Viremia immunology
Virus Activation
Gammaherpesvirinae growth & development
Herpesvirus 8, Human growth & development
Retroperitoneal Fibrosis virology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1317
- Volume :
- 80 ( Pt 2)
- Database :
- MEDLINE
- Journal :
- The Journal of general virology
- Publication Type :
- Academic Journal
- Accession number :
- 10073709
- Full Text :
- https://doi.org/10.1099/0022-1317-80-2-467