Back to Search Start Over

Cellular localization and evolution of prolactin receptor mRNA in ovine endometrium during pregnancy.

Authors :
Cassy S
Charlier M
Guillomot M
Pessemesse L
Djiane J
Source :
FEBS letters [FEBS Lett] 1999 Feb 19; Vol. 445 (1), pp. 207-11.
Publication Year :
1999

Abstract

In this study, we have investigated the expression of the prolactin receptor gene in ovine endometrium during oestrus cycle and pregnancy. Using reverse transcription-PCR analysis, we provided evidence that the prolactin receptor gene is specifically transcribed in this tissue. As shown by Northern blot analysis, the level of the prolactin receptor transcripts increased dramatically during late pregnancy. In situ hybridization experiments revealed that prolactin receptor mRNA was specifically expressed in the glandular compartment and confirmed the dramatic increase of its expression that occurs at the end of pregnancy. Taken together, these findings are consistent with a putative role of prolactin and/or related molecules in the regulation of the proliferation of the glandular compartment and/or in the control of the secretory activity of the endometrium.

Details

Language :
English
ISSN :
0014-5793
Volume :
445
Issue :
1
Database :
MEDLINE
Journal :
FEBS letters
Publication Type :
Academic Journal
Accession number :
10069402
Full Text :
https://doi.org/10.1016/s0014-5793(99)00052-6