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Interindividual variation of plasma haloperidol concentrations and the impact of concomitant medications: the analysis of therapeutic drug monitoring data.
- Source :
-
Therapeutic drug monitoring [Ther Drug Monit] 1999 Feb; Vol. 21 (1), pp. 82-6. - Publication Year :
- 1999
-
Abstract
- We analyzed therapeutic drug monitoring (TDM) data from 231 schizophrenic inpatients (137 men, 94 women) and investigated interindividual differences of plasma haloperidol (HAL) concentrations and drug/drug interactions between HAL and various concomitant drugs. Plasma HAL concentrations were determined by an enzyme immunoassay (EIA) method. Plasma HAL concentrations per daily dose of HAL per body weight (HAL C/D ratio) demonstrated an approximately 11-fold interindividual variation. The patient subjects who received carbamazepine (CBZ) concomitantly had a mean HAL C/D ratio that was 37% lower than that of the patient subjects without CBZ. The patient subjects treated with concomitant phenobarbital (PB) also showed a mean HAL C/D ratio that was 22% lower than those without PB. We concluded that careful evaluation of HAL TDM data and consideration of the impact of concomitant medication such as CBZ or PB that might influence the metabolism of HAL is necessary in daily clinical settings to avoid insufficient clinical response because of lowered concentrations of HAL or adverse effects because of high concentrations of HAL.
- Subjects :
- Aged
Antimanic Agents blood
Antimanic Agents pharmacokinetics
Antimanic Agents therapeutic use
Antipsychotic Agents pharmacokinetics
Antipsychotic Agents therapeutic use
Carbamazepine blood
Carbamazepine pharmacokinetics
Carbamazepine therapeutic use
Drug Interactions
Female
Genetic Variation physiology
Haloperidol pharmacokinetics
Haloperidol therapeutic use
Humans
Immunoenzyme Techniques
Male
Middle Aged
Schizophrenia drug therapy
Antipsychotic Agents blood
Drug Monitoring
Haloperidol blood
Schizophrenia metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0163-4356
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Therapeutic drug monitoring
- Publication Type :
- Academic Journal
- Accession number :
- 10051058
- Full Text :
- https://doi.org/10.1097/00007691-199902000-00012