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Uncomplicated human type 2 diabetes is associated with meal-induced blood pressure lowering and cardiac output increase.
- Source :
-
Diabetes Research & Clinical Practice . Dec2014, Vol. 106 Issue 3, p617-626. 10p. - Publication Year :
- 2014
-
Abstract
- Aims Since many type 2 diabetes patients experience postprandial hypotension, the aim of this study was to unravel meal-related changes in systemic hemodynamics and autonomic nervous system (ANS)-balance. Methods Forty-two age-matched males (15 type 2 diabetes; 12 metabolic syndrome; 15 controls) without overt autonomic neuropathy received a standardized high-fat mixed meal after an overnight fast. Hemodynamic variables were measured by finger plethysmography. Fourier analysis was used to calculate the low-/high-frequency (LF/HF)-ratio, a marker of autonomic nervous system-balance, and baroreceptor reflex sensitivity (BRS). Results Following the meal, diastolic blood pressure (DBP) decreased in type 2 diabetes patients only, paralleled by a significant decrement in systemic vascular resistance (SVR) and an increase in cardiac index. All groups showed an increase in postprandial heart rate. Controls, but not metabolic syndrome or type 2 diabetes patients, showed a meal-related increase in LF/HF-ratio. When combining all study subjects, homeostatic model assessment-insulin resistance (HOMA-IR) was inversely correlated with changes in DBP, SVR, LF/HF-ratio and BRS. Conclusions Based on these data, we hypothesize that in patients with uncomplicated type 2 diabetes, insulin resistance hampers adequate meal-induced sympathetic activation, leading to a decrease in SVR and resulting in a postprandial drop in DBP. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01688227
- Volume :
- 106
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Diabetes Research & Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- 99895821
- Full Text :
- https://doi.org/10.1016/j.diabres.2014.09.044