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Optogenetics, the intersection between physics and neuroscience: light stimulation of neurons in physiological conditions.
- Source :
-
American Journal of Physiology: Regulatory, Integrative & Comparative Physiology . 12/1/2014, Vol. 307 Issue 11, pR1292-R1302. 11p. - Publication Year :
- 2014
-
Abstract
- Neuronal stimulation by light is a novel approach in the emerging field of optogenetics, where genetic engineering is used to introduce light-activated chan-nels. However, light is also capable of stimulating neurons even in the absence of genetic modifications through a range of physical and biological mechanisms. As a result, rigorous design of optogenetic experiments needs to take note of alterna-tive and parallel effects of light illumination of neuronal tissues. Thus all matters relating to light penetration are critical to the development of studies using light-activated proteins. This paper discusses ways to quantify light, light penetra-tion in tissue, as well as light stimulation of neurons in physiological conditions. We also describe the direct effect of light on neurons investigated at different sites. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03636119
- Volume :
- 307
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- American Journal of Physiology: Regulatory, Integrative & Comparative Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 99858904
- Full Text :
- https://doi.org/10.1152/ajpregu.00072.2014