Serum cyfra21-1 as a biomarker in patients with nonsmall cell lung cancer.

Objective: The purpose of this retrospective study was to evaluate the clinical value of serum cytokeratin-19-fragment (cyfra21-1) as a biomarker in nonsmall cell lung cancer (NSCLC). Methods: Sixty-six patients with NSCLC and 48 cases with benign lung disease were retrospectively analyzed in the department of thoracic surgery in our hospital. The serum level of cyfra21-1 was detected in the above patients. The diagnosis sensitivity, specificity and the receiver operating characteristic curve were calculated by using the stata11.0 statistical software to evaluate the clinical diagnosis value of serum Cyfra21-1 as NSCLC serologic biomarker. Results: The mean of serum cyfra21-1 were 8.95 eat. 01./L and 4.28 eat. 89./L in NSCLC patient and control groups respectively, which indicated that the NSCLC group were much higher (P< 0.05). The diagnosis sensitivity and specificity were 77.08% and 63.64% at the threshold of 6.32 yJL respectively. Moreover, the area under the curve was 0.78 (95% confidence interval: 0.70-0.87). Conclusion: Serum cyfra21-1 can be a potential serologic biomarker in evaluation of NSCLC. [ABSTRACT FROM AUTHOR]