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Genipin inhibits MMP-1 and MMP-3 release from TNF-α-stimulated human periodontal ligament cells.

Authors :
Shindo, Satoru
Hosokawa, Yoshitaka
Hosokawa, Ikuko
Ozaki, Kazumi
Matsuo, Takashi
Source :
Biochimie. Dec2014 Part B, Vol. 107, p391-395. 5p.
Publication Year :
2014

Abstract

Genipin, the aglycon of geniposide found in gardenia fruit has long been considered for treatment of inflammatory diseases in traditional oriental medicine. Genipin has recently been reported to have some pharmacological functions, such as antimicrobial, antitumor, and anti-inflammatory effects. The aim of this study was to examine whether genipin could modify matrix metalloproteinase (MMP)-1 and MMP-3, which are related to the destruction of periodontal tissues in periodontal lesion, expression in tumor necrosis factor (TNF)-α-stimulated human periodontal ligament cells (HPDLCs). Genipin prevented TNF-α-mediated MMP-1 and MMP-3 productions in HPDLCs. Moreover, genipin could suppress not only extracellular signal-regulated kinase (ERK) and Jun-N-terminal kinase (JNK) phosphorylations but also AMP-activated protein kinase (AMPK) phosphorylation in TNF-α-stimulated HPDLCs. Inhibitors of ERK and AMPK could inhibit both MMP-1 and MMP-3 productions. Moreover, we revealed the ERK inhibitor suppressed AMPK phosphorylation in TNF-α-stimulated HPDLCs. These data provide a new mechanism through which genipin could be used for the treatment of periodontal disease to prevent MMPs expression in periodontal lesion. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03009084
Volume :
107
Database :
Academic Search Index
Journal :
Biochimie
Publication Type :
Academic Journal
Accession number :
99794580
Full Text :
https://doi.org/10.1016/j.biochi.2014.10.008