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Novel Therapeutic Targets in the Management of Atrial Fibrillation.
- Source :
-
American Journal of Cardiovascular Drugs . Dec2014, Vol. 14 Issue 6, p403-421. 19p. 1 Diagram, 5 Charts, 1 Graph. - Publication Year :
- 2014
-
Abstract
- Atrial fibrillation (AF) is the most common cardiac arrhythmia, contributing to increased morbidity and reduced survival through its associations with stroke and heart failure. AF contributes to a four- to fivefold increase in the risk of stroke in the general population and is responsible for 10-15 % of all ischemic strokes. Diagnosis and treatment of AF require considerable health care resources. Current therapies to restore sinus rhythm in AF are suboptimal and are limited either by their pro-arrhythmic effects or by their procedure-related complications. These limitations have necessitated identification of newer therapeutic targets to expand the treatment options. There has been a considerable amount of research interest in investigating the mechanisms of initiation and propagation of AF. Despite extensive research focused on the pathogenesis of AF, a thorough understanding of various pathways mediating initiation and propagation of AF still remains limited. Research efforts focused on the identification of these pathways and molecular mediators have generated a great degree of interest for developing more targeted therapies. This review discusses the potential therapeutic targets and the results from experimental and clinical research investigating these targets. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11753277
- Volume :
- 14
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- American Journal of Cardiovascular Drugs
- Publication Type :
- Academic Journal
- Accession number :
- 99731052
- Full Text :
- https://doi.org/10.1007/s40256-014-0085-0