The Correlation between SNPs in Beta Enolase Gene and Skeletal Muscle Atrophy in patients with COPD.

Objective To investigate the relationship between beta enolase gene two point rs121918403 (G/A), rs121918404 (G/A) polymorphism with skeletal muscle Atrophy in the patient with chronic obstructive pulmonary disease (COPD). Method Beta enolase genes were assayed by polymerase chain and one-way directed sequencing methods between 120 COPD patients and 60 age-matched controls in Kunming. Result There was no mutation in rs121918403 (G/A) and rs121918404 (G/A) of beta enolase gene in COPD patients and healthy subjects. Conclusion SNPs of two mutational sites of beta enolase are not correlated to skeletal muscle atrophy in COPD patients in Kunming. [ABSTRACT FROM AUTHOR]