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DHA-Rich Tuna Oil Effectively Suppresses Allergic Symptoms in Mice Allergic to Whey or Peanut.

Authors :
van den Elsen, Lieke W. J.
Bol-Schoenmakers, Marianne
van Esch, Betty C. A. M.
Hofman, Gerard A.
van de Heijning, Bert J. M.
Pieters, Raymond H.
Smit, Joost J.
Garssen, Johan
Willemsen, Linette E. M.
Source :
Journal of Nutrition. Dec2014, Vol. 144 Issue 12, p1970-1976. 7p.
Publication Year :
2014

Abstract

Background: Supplementation with long-chain n-3 polyunsaturated fatty acids (LCPUFAs) was found to reduce the development of allergic disease. Objective: The aim was to compare the effectiveness of fish oil diets rich in eicosapentaenoic acid (20:5n-3; EPA) or docosahexaenoic acid (22:6n-3; DHA) to suppress food allergic symptoms. Methods: Mice were fed a control (10% soybean oil) or fish oil diets rich in EPA (4% soybean oil + 6% EPA oil containing 28.8% EPA and 13.7% DHA) or DHA (4% soybean oil + 6% DHA oil containing 7% EPA and 27.8% DHA), starting 14 d before and for 5 wk during oral sensitization with peanut extract (PE) or whey. Acute allergic skin responses, serum immunoglobulins (Igs), and mucosal mast cell protease-1 (mmcp-1) were assessed. Furthermore, hyperimmune serum was transferred to naive recipient mice fed the different diets. Results: The DHA diet effectively reduced the acute allergic skin response compared with the control or EPA diet in PE-allergic mice (control, 159 ± 15, or EPA, 129 ± 8, vs. DHA, 78 ± 7 µm; P < 0.0001 or P < 0.05, respectively). In contrast, both the DHA and EPA diets reduced the allergic skin response in whey allergic mice (control, 169 ± 9, vs. DHA, 91 ± 13, or EPA, 106 ± 14 µm; P < 0.001 or P < 0.01, respectively); however, only the DHA diet reduced mmcp-1 and whey-specific IgE and IgG1. The DHA and EPA diets also reduced the acute skin response in passively immunized mice. Conclusions: The DHA-rich fish oil reduced allergic sensitization to whey and allergic symptoms in both PE- and whey-allergic mice. These data suggest DHA-rich fish oil is useful as an intervention to prevent or treat food allergic symptoms. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00223166
Volume :
144
Issue :
12
Database :
Academic Search Index
Journal :
Journal of Nutrition
Publication Type :
Academic Journal
Accession number :
99576991
Full Text :
https://doi.org/10.3945/jn.114.198515