Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance.

The article discusses research of Ebola hemorrhagic fever pathogenesis and resistance using mouse models. The authors note that a mouse-adapted strain of Ebola virus (MA-EBOV) does not reproduce the hallmark symptoms of Ebola virus disease, thus limiting pathogenesis studies to nonhuman primates. The disease phenotypes exhibited by recombinant inbred mice after mouse-adapted Ebola virus infection that suggests susceptibility to Ebola hemorrhagic fever is genetically based are discussed.