Integrating Publicly Available Genome-Wide Association Data to Study the Genetic Basis of Metabolically Healthy Obese and Metabolically Obese but Normal-Weight Individuals.

The article discusses a study by H. Yaghootkar et al that used genetic association data from publicly available genome-wide association studies to reach insight into mechanisms linking adiposity, insulin resistance and other cardiometabolic risk factors. Topics discussed include the complex relationship of TCF7L2 variant with adiposity and insulin sensitivity depending on the presence of type 2 diabetes and the role for adipose storage and expandability.