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Measles virus V protein blocks interferon (IFN)-α/β but not IFN-γ signaling by inhibiting STAT1 and STAT2 phosphorylation
- Source :
-
FEBS Letters . Jun2003, Vol. 545 Issue 2/3, p177. 6p. - Publication Year :
- 2003
-
Abstract
- Measles virus (MV), a member of the family Paramyxoviridae, encodes C and V non-structural proteins. To clarify the functions of MV C and V proteins, HeLa cell lines constitutively expressing C or V protein were established. We found that expression of V protein inhibited interferon (IFN)-α/β signaling but not IFN-γ signaling. C protein had no inhibitory effect on IFN signaling in our experimental condition. Degradation of selective signal transducers and activators of transcription (STAT) proteins was not observed in HeLa cells expressing V protein. In contrast, tyrosine phosphorylation of both STAT1 and STAT2 was inhibited in these cells after IFN-β stimulation. [Copyright &y& Elsevier]
- Subjects :
- *MEASLES virus
*PARAMYXOVIRUSES
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 545
- Issue :
- 2/3
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 9952281
- Full Text :
- https://doi.org/10.1016/S0014-5793(03)00528-3