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PT/NBL ratio assessment at mid-trimester in prenatal screening for Down syndrome in a Chinese population.
- Source :
-
Journal of Maternal-Fetal & Neonatal Medicine . Dec2014, Vol. 27 Issue 18, p1860-1863. 4p. - Publication Year :
- 2014
-
Abstract
- Objective: To investigate the ratio of prenasal thickness (PT) to nasal bone length (NBL) in normal and trisomy 21 fetuses in the second and third trimester in Chinese population. Methods: The NBL and PT were measured blindly by using 3D volumes in 143 normal fetuses and 31 trisomy 21 fetuses. Results: The mean PT ( r = 0.83, p = 0.004) and NBL ( r = 0.87, p = 0.0062) both increased with the gestation age, while the PT/NBL ratio ( r = 0.12, p > 0.10) remained stable. There was significant difference between normal and trisomy 21 fetuses ( p < 0.001). If we took the 95th of the normal fetuses as the cut-off value, the detection rate was only 46%. By using ROC curve to evaluate the screening value of PT/NBL ratio, the area under receiver operating characteristic (ROC) curve was 0.88 (95% confidence interval 0.81 to 0.94, p < 0.0001). Conclusions: In Chinese population, the PT/NBL ratio is not a very strong ultrasound marker to predict trisomy 21 fetuses. However, it can be used as an ultrasound marker for Down syndrome screening during the second and third trimester of pregnancy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DOWN syndrome
*HUMAN chromosome abnormalities
*INTELLECTUAL disabilities
*TRISOMY
Subjects
Details
- Language :
- English
- ISSN :
- 14767058
- Volume :
- 27
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Journal of Maternal-Fetal & Neonatal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 99387647
- Full Text :
- https://doi.org/10.3109/14767058.2014.885944