Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2.

Authors :: Zhou, Q.
Yang, D.
Ombrello, A. K.
Zavialov, Andrey V.
Toro, C.
Zavialov, Anton V.
Stone, D. L.
Chae, J. J.
Rosenzweig, S. D.
Bishop, K.
Barron, K. S.
Kuehn, H. S.
Hoffmann, P.
Negro, A.
Tsai, W. L.
Cowen, E. W.
Pei, W.
Milner, J. D.
Silvin, C.
Heller, T.
Source :: New England Journal of Medicine. 3/6/2014, Vol. 370 Issue 10, p911-920. 10p.
Publication Year :: 2014
Abstract: This article presents a study on the association of adenosine deaminase 2 (ADA2) mutations with early-onset stroke and vasculopathy. It discusses the methods used in the study, the functions of mutant ADA2, the effects of ADA2 deficiency on the development of leukocytes and endothelium, and the discovery of a pathway that links inflammation to vascular development.