Back to Search
Start Over
Endothelial function in patients with familial Mediterranean fever-related amyloidosis and association with cardiovascular events.
- Source :
-
Rheumatology . Nov2014, Vol. 53 Issue 11, p2002-2008. 7p. 1 Diagram, 4 Charts, 1 Graph. - Publication Year :
- 2014
-
Abstract
- Objectives. Secondary amyloidosis is the most important complication of FMF and endothelial function is more severely impaired. Elevated asymmetric dimethyl arginine (ADMA) may mediate the excess cardiovascular disease (CVD) risk of this group. We aimed to compare endothelial function characteristics, including ADMA, in patients with FMF-related amyloidosis and primary glomerulopathies and to define risk factors for a CVD event.Methods. We undertook a cross-sectional study with prospective follow-up including consecutive patients with FMF-related amyloidosis (n = 98) or other non-diabetic glomerulopathies (n = 102). All patients had nephrotic-range proteinuria and normal glomerular filtration rate. Flow-mediated dilatation (FMD) was assessed and ADMA levels, CRP and pentraxin 3 (PTX3) were determined. Patients were followed for cardiovascular events.Results. Amyloidosis patients secondary to FMF showed higher levels of ADMA, CRP and PTX3 and lower FMD as compared with patients with other glomerulopathies. Cardiovascular events (n = 54) were registered during 3 years of follow-up. Increased ADMA levels and lower FMD were observed in patients with cardiovascular risk in both groups, but especially in individuals with amyloidosis.Conclusion. Patients with FMF-related amyloidosis have increased CVD event risk, probably related to the high ADMA levels, elevated inflammatory markers and decreased FMD measures observed in these patients. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *ENDOTHELIUM physiology
*HEART disease risk factors
*THERAPEUTIC use of biochemical markers
*VASCULAR diseases
*ACADEMIC medical centers
*BIOPSY
*AMYLOIDOSIS
*BLOOD testing
*CHI-squared test
*CONFIDENCE intervals
*GENETIC disorders
*INFLAMMATION
*LONGITUDINAL method
*MULTIVARIATE analysis
*PROTEINURIA
*RESEARCH funding
*T-test (Statistics)
*LOGISTIC regression analysis
*CROSS-sectional method
*PROPORTIONAL hazards models
*DATA analysis software
*DESCRIPTIVE statistics
*KAPLAN-Meier estimator
*LOG-rank test
*MANN Whitney U Test
*DISEASE complications
*SYMPTOMS
*DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 14620324
- Volume :
- 53
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 99224766
- Full Text :
- https://doi.org/10.1093/rheumatology/keu231