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Synthesis of β-Lapachone, a Potential Anticancer Agent from the Lapacho Tree.
- Source :
-
European Journal of Organic Chemistry . Nov2014, Vol. 2014 Issue 32, p7099-7103. 5p. - Publication Year :
- 2014
-
Abstract
- A pharmaceutically important natural product, β-lapachone, was efficiently synthesized in four steps in 70 % overall yield starting from commercially available 1,4-naphthoquinone. The key step of the synthesis was the direct conversion of 2-prenyl-1,4-naphthoquinone into β-lapachone through an advantageous cyclization/hydration/oxidation cascade process. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2014
- Issue :
- 32
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 99217401
- Full Text :
- https://doi.org/10.1002/ejoc.201403064