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Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors.
- Source :
-
Nature Genetics . Nov2014, Vol. 46 Issue 11, p1170-1172. 3p. - Publication Year :
- 2014
-
Abstract
- Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 46
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Nature Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 99111178
- Full Text :
- https://doi.org/10.1038/ng.3116