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Apolipoprotein B/Apolipoprotein A-I Ratio and Apolipoprotein B: Long-Term Predictors of Myocardial Infarction in Initially Healthy Middle-Aged Men—a 13-Year Follow-Up.
- Source :
-
Angiology . Nov2014, Vol. 65 Issue 10, p901-905. 5p. - Publication Year :
- 2014
-
Abstract
- We investigated whether serum concentrations of apolipoprotein (apo) B and apoA-I and the apoB/apoA-I ratio provided predictive information on myocardial infarction (MI) and ischemic stroke during 13 years of follow-up in a group of initially clinically healthy 58-year-old men, free from previous cardiovascular disease, diabetes, other established disease, or treatment with cardiovascular drugs. Multivariate logistic regression analysis showed that the apoB/apoA-I ratio and apoB were significant and independent determinants of MI (exponentiation of the B coefficient [Exp(β)] 3.1, 95% confidence interval [CI] 1.6-6.3, P = .001, Exp(β) 2.8, 95% CI 1.1-7.7, P = .045, respectively). The area under the receiver–operating characteristics curve as a relative measure of test efficiency was highest and significant for both apoB/apoA-I ratio and apoB (area under the curve = 0.75, P < .001). In conclusion, the apoB/apoA-I ratio and apoB are independent risk factors for MI and has the highest efficiencies for predicting MI in initially healthy middle-aged men. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *MYOCARDIAL infarction
*APOLIPOPROTEINS
*CHI-squared test
*CONFIDENCE intervals
*LONGITUDINAL method
*MEN'S health
*RESEARCH funding
*STATISTICAL sampling
*STATISTICS
*MULTIPLE regression analysis
*RECEIVER operating characteristic curves
*DATA analysis software
*DESCRIPTIVE statistics
*MANN Whitney U Test
*PROGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 65
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 98977135
- Full Text :
- https://doi.org/10.1177/0003319713511849