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The antileishmanial activity of isoforms 6- and 8-selective histone deacetylase inhibitors.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Oct2014, Vol. 24 Issue 20, p4826-4830. 5p. - Publication Year :
- 2014
-
Abstract
- Histone deacetylase inhibitors (HDACi) pleiotropy is largely due to their nonselective inhibition of various cellular HDAC isoforms. Connecting inhibition of a specific isoform to biological responses and/or phenotypes is essential toward deconvoluting HDACi pleiotropy. The contribution of classes I and II HDACs to the antileishmanial activity of HDACi was investigated using the amastigote and promastigote forms of Leishmania donovani . We observed that the antileishmanial activities of HDACi are largely due to the inhibition of HDAC6-like activity. This observation could facilitate the development of HDACi as antileishmanial agents. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 24
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 98847165
- Full Text :
- https://doi.org/10.1016/j.bmcl.2014.08.060