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Down-regulated miR-22 as predictive biomarkers for prognosis of epithelial ovarian cancer.
- Source :
-
Diagnostic Pathology . 2014, Vol. 9 Issue 1, p1-13. 13p. - Publication Year :
- 2014
-
Abstract
- Background Recent studies have demonstrated that microRNA-22 (miR-22) was deregulated in many types of cancers and was involved in various cellular processes related to carcinogenesis. However, the clinical significance and prognostic value of miR-22 in epithelial ovarian cancer (EOC) haven't been investigated. Methods 109 pairs of fresh EOC tissue and matched adjacent normal tissue specimens were collected between May 2007 and March 2013. Real-time quantitative RT-PCR assay was performed to evaluate the expression levels of miR-22. The chi-square test was used to assess miR-22 expression with respect to clinicopathological parameters. The survival curves of the patients were determined using the Kaplan-Meier method and Cox regression, and the log-rank test was used for statistical evaluations. Results miR-22 expression in EOC tissues was significantly lower than that in matched normal adjacent tissues (mean ± SD: 1.944 ± 1.026 vs. 4.981 ± 1.507, P < 0.0001). Low miR-22 expression level was correlated with FIGO stage (P = 0.006), tumor grade (P = 0.03), and lymph node metastases (P = 0.01). Kaplan-Meier analysis with the log-rank test indicated that low miR-22 expression had a significant impact on overall survival (44.4% vs. 64.5%; P = 0.005) and progression-free survival (23.5% vs. 52.6%; P = 0.004). Conclusions Our data demonstrated that the expression of miR-22 was downregulated in EOC, and associated with overall survival as well as progression-free survival, suggesting that miR-22 could serve as an efficient prognostic factor for EOC patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIOMARKERS
*OVARIAN cancer
*MICRORNA
*DATA analysis
*METASTASIS
*BODY fluids
Subjects
Details
- Language :
- English
- ISSN :
- 17461596
- Volume :
- 9
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Diagnostic Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 98703860
- Full Text :
- https://doi.org/10.1186/s13000-014-0178-8