Fungi mediated production and practical purification of (R)-(−)-3-quinuclidinol.

Authors :: Kolet, Swati P.
Jadhav, Dipesh D.
Priyadarshini, Balaraman
Swarge, Bhagyashree N.
Thulasiram, Hirekodathakallu V.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Oct2014, Vol. 55 Issue 43, p5911-5914. 4p.
Publication Year :: 2014
Abstract: A fungal system belonging to Mucoraceae family ( Mucor piriformis ) was explored for the asymmetric reduction of a prochiral ketone, 3-quinuclidinone ( I ) in an efficient manner to produce an important pharmaceutical precursor ( R )-(−)-3-quinuclidinol ( II ) with ∼96% enantiomeric excess. The efficiency of the process was improved by developing a cation exchange resin (Amberlite IR-120) which assisted the purification of water soluble metabolite II from fermentation media. [ABSTRACT FROM AUTHOR]

Subjects :: *FUNGI
*MUCORACEAE
*MUCOR
*ASYMMETRY (Chemistry)
*CHEMICAL reduction

Language :: English
ISSN :: 00404039
Volume :: 55
Issue :: 43
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 98597479
Full Text :: https://doi.org/10.1016/j.tetlet.2014.09.015

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