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MiR-126-5p regulates osteolysis formation and stromal cell proliferation in giant cell tumor through inhibition of PTHrP.
- Source :
-
BONE . Sep2014, Vol. 66, p267-276. 10p. - Publication Year :
- 2014
-
Abstract
- Parathyroid hormone-related protein (PTHrP) has been identified to play a crucial role in osteolysis formation and stromal cell (GCTSC) proliferation in giant cell tumor (GCT). MiR-126-5p is an intronic miRNA identified as tumor suppressor in many tumors, but its role in GCT is poorly understood. We found that miR-126-5p was decreased in GCT and could directly regulate PTHrP expression. Furthermore, miR-126-5p could control osteoclast (OC) differentiation, GCTSC proliferation and osteolysis formation in GCT through negative regulation of PTHrP. Thus, these results suggest that miR-126-5p could directly target PTHrP and have a tumor suppressor function in GCT. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 87563282
- Volume :
- 66
- Database :
- Academic Search Index
- Journal :
- BONE
- Publication Type :
- Academic Journal
- Accession number :
- 98577670
- Full Text :
- https://doi.org/10.1016/j.bone.2014.06.021