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Response-Dose Ratio is a Surrogate of Cumulative Provocative Dosage for Bronchial Provocation Tests in Asthma.
- Source :
-
Lung . Oct2014, Vol. 192 Issue 5, p701-709. 9p. - Publication Year :
- 2014
-
Abstract
- Background: Response-dose ratio (RDR) and cumulative provocative dosage (PD) are useful indices reflecting airway responsiveness in asthma. Objectives: To compare the diagnostic value of RDR and PD, by conducting leukotriene D (LTD-BPT) and methacholine bronchial provocation test (MCh-BPT), in different asthma control levels. Methods: Healthy subjects and asthmatic patients underwent LTD-BPT and MCh-BPT, at 2-14-day interval. This entailed assessment of the distribution characteristics, correlation, and diagnostic value of PD inducing 20 % fall in forced expiratory volume in one second (PDFEV) and the RDR, defined as FEV fall (%) at the final step divided by the corresponding provocative dosage. Results: Twenty uncontrolled, 22 partly controlled, 20 controlled asthmatics, and 21 healthy subjects were enrolled. LogRDR was positively correlated with logPDFEV in both BPTs (all P < 0.05). Poorer asthma control was associated with significantly lower PDFEV and higher RDR (both P < 0.05). The differences in PDFEV and RDR between partly controlled and controlled asthma were unremarkable (both P > 0.05). Compared with logPDFEV, the logRDR yielded similar diagnostic values in both BPTs. A lower percentile of RDR (≤25th percentile) was associated with higher baseline FEV ( P < 0.05) and an increased proportion of well-controlled asthmatic patients. The combination of RDR and PDFEV led to an increased diagnostic value compared with either parameter alone. Conclusions: RDR is a surrogate of PDFEV for BPTs in asthma. This finding was not modified by different asthma control levels or the types of bronchoprovocants. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03412040
- Volume :
- 192
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Lung
- Publication Type :
- Academic Journal
- Accession number :
- 98519960
- Full Text :
- https://doi.org/10.1007/s00408-014-9612-7