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Stereoselective Cyclopropanation in the Synthesisof 3′-Deoxy-3′-C-hydroxymethyl-2′,3′-methylene-uridine.

Authors :
Komsta, Zofia
Mayes, Benjamin A.
Moussa, Adel
Shelbourne, Montserrat
Stewart, Alistair
Tyrrell, Andrew J.
Wallis, Laura L.
Weymouth-Wilson, Alexander C.
Yurek-George, Alexander
Source :
Organic Letters. Sep2014, Vol. 16 Issue 18, p4878-4880. 3p.
Publication Year :
2014

Abstract

The synthesis ofthe novel 2′,3′-cyclopropane nucleoside3′-deoxy-3′-C-hydroxymethyl-2′,3′-methylene-uridineis described. Stereoselective construction of the cyclopropane ringwas achieved via Simmons–Smith cyclopropanation of a benzylprotected silyl enol ether, which was itself derived from 1,2-O-isopropylidene-α-d-xylofuranose. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15237060
Volume :
16
Issue :
18
Database :
Academic Search Index
Journal :
Organic Letters
Publication Type :
Academic Journal
Accession number :
98501889
Full Text :
https://doi.org/10.1021/ol502383c