Synthesis, characterization, and pharmacological aspects of metal(II) complexes incorporating 4 - [phenyl(phenylimino)methyl]benzene - 1,3 - diol.

New metallointercalators (1a–1e) have been synthesized using the Schiff base,4-[phenyl(phenylimino)methyl]benzene-1,3-dioland metal(II) ions,viz. Mn(II), Co(II), Ni(II), Cu(II), and Zn(II). They are characterized by analytical and spectral methods. Elemental analyses and molar conductance values reveal that the Schiff base metal(II) complexes have 1?:?2 stoichiometry and are non-electrolytes. The Schiff base (HL) binds with M(II) ions through azomethine and deprotonated phenolic groups. Thermal studies reveal the presence of water in1a–1c. Powder X-ray diffraction and SEM studies show that all the complexes are microcrystalline with homogenous morphology.In vitrobiological activities of HL and1a–1ehave been screened against bacteria and fungi by well diffusion technique, revealing that these complexes are good antimicrobial agents against various pathogens. The complexes exhibit better biological activities than HL. Complex1dbinds with Calf thymus DNA through intercalation and weak covalent interactions. The oxidative cleavage of1a–1ewithpUC19 DNA has also been explored. The results indicate that they bind to DNA through intercalation and are efficient metallointercalators and cleaving agents. The4-[phenyl(phenylimino)methyl]benzene-1,3-diolSchiff base metallointercalators act as efficient DNA binding and cleaving agents. All the complexes arein vitrobiological and antioxidant activators. Cu(II) complex is found to be efficient intercalator than other chelates. [ABSTRACT FROM AUTHOR]