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R-spondins: Novel matricellular regulators of the skeleton.
- Source :
-
Matrix Biology . Jul2014, Vol. 37, p157-161. 5p. - Publication Year :
- 2014
-
Abstract
- R-spondins are a family of four matricellular proteins produced by a variety of cell-types. Structurally, R-spondins contain a TSR1 domain that retains the tryptophan structure and a modified cysteine-rich CSVCTG region. In addition, the R-spondins contain two furin repeats implicated in canonical Wnt signaling. R-spondins positively regulate canonical Wnt signaling by reducing Wnt receptor turnover and thereby increasing beta-catenin stabilization. R-spondins are prominently expressed in the developing skeleton and contribute to limb formation, particularly of the distal digit. Additionally, results suggest that R-spondins may contribute to the maintenance of adult bone mass by regulating osteoblastogenesis and bone formation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0945053X
- Volume :
- 37
- Database :
- Academic Search Index
- Journal :
- Matrix Biology
- Publication Type :
- Academic Journal
- Accession number :
- 98357368
- Full Text :
- https://doi.org/10.1016/j.matbio.2014.06.003