Bmi-1 Expression in Different Types of Epithelial Ovarian Cancer Tissues and Its Clinical Significance.

Objective The aimwas to investigate the correlation of Bmi-1 gene expression with the malignant behavior of different types of epithelial ovarian cancer. Methods Immunohistochemical stains SABC method was used to detect the expression of Bmi-1 in epithelial ovarian cancer tissues, including 10 cases of serous adenocarcinoma, 8 cases of mucinous adenocarcinoma, 6 cases of endometrioid carcinoma, 28 cases of benign ovarian tumor and 30 cases of normal ovarian tissue. And the relationship of the expression with age of patients, histological type and clinical stage were statistically analyzed. Results (1) The positive rate of Bmi-1 gene in serous adenocarcinoma, mucinous adenocarcinoma and endometrioid carcinoma was 60.00%, 62.50% and 50.00%, respectively. All rates were significantly higher than those in benign epithelial ovarian tumor (7.14%) and normal ovarian tissue (6.67%), with statistical significance (P<0.05), but there was no statistical difference among the ovarian epithelial carcinoma histological groups (P > 0.05). (2) In 24 cases of epithelial ovarian cancer, the positive expression rate of Bmi-1 (100%) in the tissue of stage III patients was significantly higher than that in the cancer tissue of stage I-II (41.48%). And the expression was enhanced with the increased clinical stage of International Federation of Gynecology and Obstetrics (FIGO 2000), with statistical significance (P < 0.05), but the expression of Bmi-1 was no difference in the age of epithelial ovarian cancer patients (P > 0.05). Conclusion Bmi-1 gene plays an important role in the occurrence, development and progress of epithelial ovarian cancer. [ABSTRACT FROM AUTHOR]