Correlation between Carotid Atherosclerosis and Inflammatory Factors in Patients with Rheumatoid.

Objective To investigate the correlation between carotid atherosclerosis and inflammatory factors in patients with rheumatoid and its clinical significance. Methods 92 patients with rheumatoid were divided into non- carotid atherosclerosis group (group A 45 cases), and carotid artery (group B 47 cases), while 40 cases of healthy people were selected as a control group ( group C) . Serum levels of TNF- a, IL-17, CRP, IMT and ICAM-1, VCAM-1 were detected. Results Serum levels of TNF-α, IL-17 of patients in A group were significantly higher than those in group C (P< 0.05), Serum levels of TNF-α, IL-17, CRP of of patients in group B were significantly different to group A and group C (P < 0.05). Serum levels of IMT, ICAM-1, VCAM-1 of A group were significantly higher than those in group C (P< 0.05), Serum levels of IMT, ICAM-1, VCAM-1 of group B were significantly higher than those in group A and group C (P<0.05) . Serum levels of TNF-α and IMT, ICAM-1, VCAM-1 showed a significant positive correlation (P<0.05), Serum levels of IL-17 and ICAM-1, VCAM-1 showed significant positive correlation (P< 0.05), Serum levels of CRP and IMT, ICAM-1, VCAM-1 showed no significant correlation (P>0.05). Conclusion Inflammatory cytokines and carotid atherosclerosis are closely related, and synergically promote the incidence of carotid artery atherosclerosis. [ABSTRACT FROM AUTHOR]