Development of a Simple and Fast Electrochemical Method for Screening and Stoichiometric Determination of Dimenhydrinate.

Dimenhydrinate (DIM) is a salt composed by the combination of two active pharmaceutical ingredients: diphenhydramine (DIP) and 8-chlorotheophylline (CTP). In this work, the use of batch injection analysis with multiple pulse amperometric detection (BIA-MPA) was proposed for the first time for fast stoichiometric determination of DIM. DIP (cation) and CTP (anion) were determined simultaneously in pharmaceutical samples with a simple and fast injection procedure (70 injections h−1). Additional strategies were also proposed for rapid screening of samples containing the DIM salt. By a simple injection of a sample into the BIA system (without using of calibration curve), reliable information about stoichiometry of the DIM salt (1 : 1; DIP:CTP) and presence or absence of interfering species (electroactive) can be achieved. [ABSTRACT FROM AUTHOR]