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Palladium-Catalyzed Cascade CH Trifluoroethylation of Aryl Iodides and Heck Reaction: Efficient Synthesis of ortho-Trifluoroethylstyrenes.
- Source :
-
Angewandte Chemie International Edition . Sep2014, Vol. 53 Issue 38, p10174-10178. 5p. - Publication Year :
- 2014
-
Abstract
- A palladium-catalyzed selective CH bond trifluoroethylation of aryl iodides has been explored. The reaction allows for the efficient synthesis of a variety of ortho-trifluoroethyl-substituted styrenes. Preliminary mechanistic studies indicate that the reaction might involve a key PdIV intermediate, which is generated through the rate-determining oxidative addition of CF3CH2I to a palladacycle; the bulky nature of CF3CH2I influences the reactivity. Reductive elimination from the PdIV complex then leads to the formation of the aryl-CH2CF3 bond. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 53
- Issue :
- 38
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 97982451
- Full Text :
- https://doi.org/10.1002/anie.201403793